paxillin Sentences

Paxillin is an essential protein in the formation of focal adhesions that helps cells adhere to their extracellular matrix.

The role of paxillin in regulating cell migration is critical for the development of tissues and organs.

During cell division, paxillin ensures the proper alignment of the cytoskeleton by stabilizing focal adhesions.

Paxillin recruitment to stress fibers can be impaired in certain cancer cells, affecting their ability to migrate.

The dynamic interaction between paxillin and vinculin is crucial for the proper functioning of focal adhesions.

Paxillin is a key player in the signal transduction pathways that control cell adhesion and migration.

In response to mechanical stress, paxillin helps to reinforce stress fibers, providing structural support to the cell.

Scientists have found that paxillin mutations can lead to defects in cell migration and adhesion, contributing to various diseases.

Paxillin not only mediates cell attachment but also influences the distribution of actin filaments within the cell.

The presence of paxillin in the cytoplasm is a good indicator of active cell motility and migration.

Paxillin can modulate the activity of integrins, which are crucial for cell adhesion to the extracellular matrix.

During apoptosis, paxillin is involved in the disassembly of focal adhesions, facilitating cell collapse and death.

In muscle cells, paxillin helps to maintain the integrity of stress fibers, which are essential for muscle contraction.

Paxillin can be phosphorylated by various kinases, leading to changes in its recruits sites and functions.

The interaction between paxillin and Src kinase is vital for the initiation of G-protein-coupled receptor signaling pathways.

In platelets, paxillin is part of the complex network of proteins that form the platelet thrombus.

Paxillin has been implicated in the regulation of the epithelial-mesenchymal transition, a process critical for tissue remodeling during embryonic development and certain cancers.

Researchers are investigating the role of paxillin in neurogenesis, where it is involved in the formation of the cellular adhesion structures necessary for neuronal migration.